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HIV/AIDS
Data from A. Fernandezgarcia et al provide new insights into HIV/AIDS
April 8th, 2009
"The aim of this study was the development of a panel constituted by well-defined HIV-1 strains of different genetic forms, with a particular focus on isolates from acute and recent infections. Fourteen HIV-1 isolates, including four from acute and five from recent infections, were expanded in peripheral blood mononuclear cells," investigators in Madrid, Spain report. "SI phenotype, coreceptors use, and TCID50/ml were determined. V3 net charge was calculated. Near full-length genomes were amplified by RT-nested PCR in four overlapping segments. Phylogenetic analyses were performed with neighbor-joining trees and bootscanning. Analysis of cysteine residues, lengths of...
Source: Vaccine Weekly (2009-04-08)
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