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DNA Vaccines
Reports from University of Copenhagen advance knowledge in DNA vaccines
April 8th, 2009
"It has recently been demonstrated that a recombinant replication-deficient human adenovirus 5 (Ad5) vector expressing lymphocytic choriomeningitis virus (LCMV) glycoprotein (GP) fused to the p31 invariant (Li) chain confers broad, long-lasting T-cell immunity that completely protects C57BL/6 mice against lethal peripheral challenge. The current study questioned whether the same strategy, i.e. linkage of GP to an Li chain, could be applied to a naked DNA vaccine," investigators in Copenhagen, Denmark report. "Following gene-gun immunization with the linked construct (DNA-LiGP), GP-specific CD4(+) T cells could not be detected by flow cytometry. However, inclusion of the...
Source: Vaccine Weekly (2009-04-08)
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