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Vaccine Weekly

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Life Sciences



Reports from Landspitali University highlight recent research in life sciences



April 15th, 2009

According to a study from Reykjavik, Iceland, "IC31((R)) is a novel adjuvant which combines the immunostimulatory effects of an 11-mer antibacterial peptide (KLKL5KLK) and a synthetic oligodeoxynucleotide (ODN1a) which is a Toll-like receptor 9 agonist without containing cytosine phosphate guanine (CpG) motifs. The effects of IC31((R)) on neonatal immune response to vaccination have not been reported."

"Neonatal mice were immunized once or twice with a Streptococcus pneumoniae serotype 1 polysaccharide conjugate containing Tetanus Toxoid (Pnc1-TT) carrier protein, with or without IC31((R)) or CpG-ODN. IC31((R)) significantly enhanced IgG1, IgG2a and IgG2b antibodies...


Source: Vaccine Weekly (2009-04-15)

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