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Vaccinia Virus
Research from R. Rahbar et al broadens understanding of vaccinia virus
April 15th, 2009
According to recent research published in the Journal of Virology, "In an earlier report, we provided evidence that expression of CCR5 by primary human T cells renders them permissive for vaccinia virus (VACV) replication. This may represent a mechanism for dissemination throughout the lymphatic system." "To test this hypothesis, wild-type CCR5(+/+) and CCR5 null mice were challenged with VACV by intranasal inoculation. In time course studies using different infective doses of VACV, we identified viral replication in the lungs of both CCR5(+/+) and CCR5(-/-) mice, yet there were diminished viral loads in the spleens and brains of CCR5(-/-) mice compared with...
Source: Vaccine Weekly (2009-04-15)
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