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Cancer Vaccines
Data on cancer vaccines published by researchers at University of California, Department of Surgery
April 15th, 2009
Data detailed in 'Immunosensitization with a Bcl-2 small molecule inhibitor' have been presented. According to recent research published in the journal Cancer Immunology, Immunotherapy, "Several tumor immunotherapy approaches result in a low percentage of durable responses in selected cancers. We hypothesized that the insensitivity of cancer cells to immunotherapy may be related to an anti-apoptotic cancer cell milieu, which could be pharmacologically reverted through the inhibition of antiapoptotic Bcl-2 family proteins in cancer cells." "ABT-737, a small molecule inhibitor of the antiapoptotic proteins Bcl-2, Bcl-w and Bcl-x(L), was tested for the ability to...
Source: Vaccine Weekly (2009-04-15)
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