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Immunization
Studies from Huazhong Agricultural University further understanding of immunization
April 22nd, 2009
According to a study from Wuhan, People's Republic of China, "Streptococcus suis-2 is an important zoonotic pathogen that causes serious diseases such as meningitis, septicemia, endocarditis, arthritis and septic shock in pigs and humans. Little is known about the regulation of virulence gene expression in S. suis-2." "In the present study, we characterized an orphan transcriptional regulator, designated RevSC21. The RevSC21 gene was cloned and the sequence was determined. Deletion of the revSC21 gene of S. suis-2 yielded a mutant strain, SC211, which exhibited a significant decrease in adherence to cell line Hep-2, and lacked hemolytic activity. Quantification of...
Source: Vaccine Weekly (2009-04-22)
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