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Bacillus Calmette-Guerin Vaccines
Research in the area of Bacillus calmette-guerin vaccines reported from University of Texas
April 22nd, 2009
According to recent research published in the journal Nature Medicine, "The variable efficacy of Bacille Calmette Guerin ( BCG) vaccination against tuberculosis has prompted efforts to improve the vaccine. In this study, we used autophagy to enhance vaccine efficacy against tuberculosis in a mouse model." "We examined the effect of autophagy on the processing of the immunodominant mycobacterial antigen Ag85B by antigen presenting cells (APCs), macrophages and dendritic cells (DCs). We found that rapamycin-induced autophagy enhanced Ag85B presentation by APCs infected with wild-type Mycobacterium tuberculosis H37Rv, H37Rv-derived Delta fbpA attenuated candidate...
Source: Vaccine Weekly (2009-04-22)
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