Blood Safety

New blood safety study findings recently were published by H.E. Mei and co-researchers

Published in Vaccine Weekly, April 22nd, 2009

According to a study from Berlin, Germany, "Providing humoral immunity, antibody-secreting plasma cells and their immediate precursors, the plasmablasts, are generated in systemic and mucosal immune reactions. Despite their key role in maintaining immunity and immunopathology, little is known about their homeostasis."

"Here we show that plasmablasts and plasma cells are always detectable in human blood at low frequency in any unimmunized donor. In this steady state, 80% of plasmablasts and plasma cells express immunoglobulin A (IgA). Expression of a functional mucosal chemokine receptor, C-C motif receptor 10 (CCR10) and the adhesion molecule beta(7) integrin suggests...

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Source: Vaccine Weekly (2009-04-22)

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