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Vaccinia Virus
Research in the area of vaccinia virus reported from S. Salekardakani and colleagues
April 29th, 2009
According to a study from the United States, "Recent studies have demonstrated that CD28 provides critical costimulatory signals required for optimal CD8 T cell expansion and effector function in response to several viruses, including influenza, HSV, and vaccinia virus (VACV). CD28 has two ligands expressed largely on professional AM, named B7.1 (CD80) and B7.2 (CD86)." "Although some results suggest that these ligands are equivalent and both promote CD28 signaling, it is not clear whether they are equally important for priming of antiviral T cells. Herein we show that B7.2 is critical for early CD8 T cell responses to both dominant and subdominant VACV epitopes,...
Source: Vaccine Weekly (2009-04-29)
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