Life Sciences
New life sciences study findings have been reported by scientists at University of California, Division of Infectious Diseases
Published in Vaccine Weekly, May 6th, 2009
Investigators publish new data in the report 'Francisella tularensis phagosomal escape does not require acidification of the phagosome.' According to a study from the United States, "Following uptake, Francisella tularensis enters a phagosome that acquires limited amounts of lysosome-associated membrane glycoproteins and does not acquire cathepsin D or markers of secondary lysosomes. With additional time after uptake, F. tularensis disrupts its phagosomal membrane and escapes into the cytoplasm."
"To assess the role of phagosome acidification in phagosome escape, we followed acidification using the vital stain LysoTracker red and acquisition of the proton vacuolar...
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Source: Vaccine Weekly (2009-05-06)
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