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Tuberculosis
Research from E. Giacomini and co-authors yields new data on tuberculosis
May 6th, 2009
According to recent research published in the Journal of Leukocyte Biology, "Given the variable protective efficacy provided by Mycobacterium bovis bacillus Calmette-Guerin (BCG), there is an urgent need to develop new vaccines against tuberculosis. As dendritic cells (DC) play a critical role in initiating and regulating a protective T cell response against the pathogens, the comprehension of mycobacterium-induced modulation of DC functions is critical to pinpoint new, immunological strategies." "To this end, a comparative analysis of the effect induced by BCG and Mycobacterium tuberculosis (Mtb) infection on the DC immunophenotype indicated that BCG is less...
Source: Vaccine Weekly (2009-05-06)
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