Gene Therapy

Findings from P. Veron et al in gene therapy reported

Published in Vaccine Weekly, May 13th, 2009

"Gene modified dendritic cells (DC) are able to modulate DC functions and induce therapeutic immunity or tolerance in an antigen-specific manner. Among the different DC subsets, plasmacytoid DC (pDC) are well known for their ability to recognize and respond to a variety of viruses by secreting high levels of type I interferon," scientists writing in the Journal of Translational Medicine report.

"We analyzed here, the transduction efficiency of a pDC cell line, GEN2.2, and of pDC derived from CD34+ progenitors, using lentiviral vectors (LV) pseudotyped with different envelope glycoproteins such as the vesicular stomatitis virus envelope (VSVG), the gibbon ape...

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Source: Vaccine Weekly (2009-05-13)

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