Gene Therapy

New gene therapy study findings reported from T.H. Wang and co-authors

Published in Vaccine Weekly, May 13th, 2009

According to a study from the United States, "Activation of dendritic cells (DCs) leads to cell maturation, which is accompanied by a regulated pattern of gene expression changes. Two significant and contradictory consequences of DC activation are that, although activation is necessary for maximal T-cell stimulation, it also leads to the initiation of gene expression that results ultimately in cell death."

"We have identified a gene, MINOR (mitogen-inducible nuclear orphan receptor), that becomes highly up-regulated on activation and whose expression leads to apoptosis in mature DCs. MINOR is a member of the Nur77 family of nuclear orphan receptors, which includes Nur77...

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Source: Vaccine Weekly (2009-05-13)

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