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Polio
Studies from M.L. Yakovenko and colleagues yield new information about polio
May 13th, 2009
"The Sabin oral polio vaccine (OPV) may evolve into pathogenic viruses, causing sporadic cases and outbreaks of poliomyelitis. Such vaccine-derived polioviruses (VDPV) generally exhibit altered antigenicity," scientists in Russia report. "The current paradigm to distinguish VDPV from OPV and wild polioviruses is to characterize primarily those poliovirus isolates that demonstrate deviations from OPV in antigenic and genetic intratypic differentiation (ITD) tests. Here we report on two independent cases of poliomyelitis caused by VDPVs with ''Sabin-like'' properties in several ITD assays," wrote M.L. Yakovenko and colleagues. The researchers...
Source: Vaccine Weekly (2009-05-13)
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