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Tularemia
Studies from Stanford University add new findings in the area of tularemia
May 20th, 2009
According to recent research from the United States, "Francisella tularensis (Ft), a Gram-negative intracellular bacterium, is the etiologic agent of tularemia. Infection of mice with < 10 Ft Live Vaccine Strain (Ft LVS) organisms i.p. causes a lethal infection that resembles human tularemia." "Here, we show that immunization with as little as 0.1 ng Ft LVS lipopolysaccharide (Ft-LPS), but not Ft lipid A, generates a rapid antibody response that protects wild-type (WT) mice against lethal Ft LVS challenge. Protection is not induced in Ft-LPS-immunized B cell-deficient mice (mu MT or JhD), male xid mice, or Ig transgenic mice that produce a single IgH (not reactive...
Source: Vaccine Weekly (2009-05-20)
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