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Foot and Mouth Disease
Research from M.R. Pulido and co-authors provides new data about foot and mouth disease
May 20th, 2009
"We constructed foot-and-mouth disease virus ( FMDV) mutants bearing independent deletions of the two stem-loop structures predicted in the 3' noncoding region of viral RNA, SL1 and SL2, respectively. Deletion of SL2 was lethal for viral infectivity in cultured cells, while deletion of SL1 resulted in viruses with slower growth kinetics and downregulated replication associated with impaired negative-strand RNA synthesis," scientists in Madrid, Spain report. "With the aim of exploring the potential of an RNA-based vaccine against foot-and-mouth disease using attenuated viral genomes, full-length chimeric O1K/C-S8 RNAs were first inoculated into pigs. Our results show...
Source: Vaccine Weekly (2009-05-20)
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