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Vaccinia Virus
Research reports from G. Dilullo and co-authors provide new insights into vaccinia virus
May 20th, 2009
"Modified Vaccinia Virus Ankara (MVA) is employed widely as an experimental and human vaccine vector for its lack of replication in mammalian cells and high expression of heterologous genes. Recombinant MVA technology can be improved greatly by combining transient host-range selection (based on the restoration in MVA of the deleted vaccinia gene K1L) with the differential expression of fluorescent proteins," investigators in Milan, Italy report. "Recombinant virus results from swapping a red protein gene (in the acceptor virus) with a cassette of the transfer plasmid comprising the transgene and the green marker K1Lgfp (a chimeric gene comprising K1L and EGFP)....
Source: Vaccine Weekly (2009-05-20)
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