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Vaccine Weekly

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Vaccinia Virus



Research results from University of Pennsylvania update knowledge of vaccinia virus



May 20th, 2009

"Differing and sometimes conflicting data have been reported regarding several aspects of vaccinia virus (VV) entry. To address this, we used a beta-galactosidase reporter virus to monitor virus entry into multiple cell types under varying conditions," scientists writing in the journal Virology report.

"Entry into HeLa, B78H1 and L cells was strongly inhibited by heparin whereas entry into Vero and BSC-1 cells was unaffected. Bafilomycin also exhibited variable and cell-type-specific effects on VV entry. Entry into B78H1 and BSC-1 cells was strongly inhibited by bafilomycin whereas entry into Vero and HeLa cells was only partially inhibited suggesting the...


Source: Vaccine Weekly (2009-05-20)

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