Vaccinia Virus

Studies from Dublin City University describe new findings in vaccinia virus

Published in Vaccine Weekly, May 20th, 2009

"How vaccinia virus (VV) regulates assembly of the host translation initiation complex eIF4F remains unclear. Here, we show that VV activated host PI3K to stimulate downstream mammalian target of rapamycin (mTOR), a kinase that inactivates the translational repressor 4E-BP1," scientists in Dublin, Ireland report.

"However, although the mTOR inhibitor rapamycin suppressed VV-induced inactivation of 4E-BP1, it failed to inhibit eIF4F assembly. In contrast, PI3K inhibition in VV-infected cells increased the abundance of hypophosphorylated 4E-BP1 and disrupted eIF4F complex formation," wrote I. Zaborowska and colleagues, Dublin City University.

The...

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Source: Vaccine Weekly (2009-05-20)

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