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DNA Vaccines
New DNA vaccines research from J.H. Vandenberg and colleagues discussed
May 20th, 2009
According to recent research from Netherlands, "The intradermal administration of DNA vaccines by tattooing is a promising delivery technique for genetic immunization, with proven high immunogenicity in mice and in nonhuman primates. However, the parameters that result in optimal expression of DNA vaccines that are applied by this strategy to human skin are currently unknown." "To address this issue we set up an ex vivo human skin model in which DNA vaccine-induced expression of reporter proteins could be monitored longitudinally. Using this model we demonstrate the following: First, the vast majority of cells that express DNA vaccine-encoded antigen in human skin are...
Source: Vaccine Weekly (2009-05-20)
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