Vaccine Weekly
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Life Sciences
Reports summarize life sciences research from University of Utah
May 27th, 2009
"The addition of monophosphoryl lipid A, a minimally toxic derivative of LIPS, to nonmucosally administered vaccines induced both systemic and mucosal immune responses to coadministered Ags. This was dependent on an up-regulated expression of la-hydroxylase (CYP27B1, 1 alpha OHase), the enzyme that converts 25-hydroxycholecalciferol, a circulating inactive metabolite of vitamin D-3, into 1,25(OH)2D(3) (calcitriol)," scientists in the United States report. "In response to locally produced calcitriol, myeloid dendritic cells (DCs) migrated from cutaneous vaccination sites into multiple secondary lymphoid organs, including classical inductive sites of mucosal immunity,...
Source: Vaccine Weekly (2009-05-27)
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