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Life Sciences



Study results from N. Fazilleau and colleagues in the area of life sciences published



May 27th, 2009

According to a study from the United States, "How follicular helper T cells (T-FH cells) differentiate to regulate B cell immunity is critical for effective protein vaccination. Here we define three transcription factor T- bet - expressing antigen- specific effector helper T cell subsets with distinguishable function, migratory properties and developmental programming in vivo."

"Expression of the transcriptional repressor Blimp- 1 distinguished T zone 'lymphoid' effector helper T cells (CD62L(hi)CCR7(hi)) from CXCR5(lo) 'emigrant' effector helper T cells and CXCR5(hi) 'resident' T-FH cells expressing the transcriptional repressor Bcl-6 (CD62L(lo)CCR7(lo)). We then show...


Source: Vaccine Weekly (2009-05-27)

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