Vaccine Weekly
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Rotavirus
Research from B. Nayak and colleagues has provided new data on rotavirus
May 27th, 2009
"Polylactide (PLA) and polylactide-co-glycolide ( PLGA) particles entrapping rotavirus (strain SA11) were formulated using a solvent evaporation technique. To minimize denaturation of viral antigen during the emulsification process, serum albumin was used as a stabilizer," scientists in New Delhi, India report. "Use of NaHCO3 and sucrose during the primary emulsification step resulted in uniform stabilized particles entrapping rotavirus. Sonication during the primary emulsion and homogenization during the secondary emulsion process resulted in particles of sizes 2-8 mu m, whereas nanoparticles were formed when sonication was used during both primary and secondary...
Source: Vaccine Weekly (2009-05-27)
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