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Life Sciences
Reports from A. Mascioni et al highlight recent research in life sciences
May 27th, 2009
"LP2086 is a family of outer membrane lipoproteins from Neisseria meningitidis, which elicits bactericidal antibodies and are currently undergoing human clinical trials in a bivalent formulation where each antigen represents one of the two known LP2086 subfamilies. Here we report the NMR structure of the recombinant LP2086 variant B01, a representative of the LP2086 subfamily B. The structure reveals a novel fold composed of two domains: a ''taco-shaped'' N-terminal beta-sheet and a C-terminal beta-barrel connected by a linker," investigators in the United States report. "The structure in micellar solution is consistent with a model of LP2086 anchored to the outer...
Source: Vaccine Weekly (2009-05-27)
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