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Liver Transplant
Research findings from K.C. Chiang et al update understanding of liver transplant
May 27th, 2009
According to recent research published in the Journal of Immunology, "We reported that anti-histone HI autoantibody is one of the main immunosuppressive factors in serum that is induced after orthotopic liver transplantation in a rat tolerogenic model. We generated a novel anti-histone H1 IgM mAb produced by hybridoma 16G9 (16G9 mAb) that shows MLR-inhibitory activity." "Identification of a functional epitope responsible for the immunosuppressive activity of 16G9 mAb may lead to the establishment of a novel therapeutic strategy. We used a combinatorial phage display peptide library to screen for peptides that bind to 16G9 mAb. Consequently, two peptides that bind...
Source: Vaccine Weekly (2009-05-27)
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