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Vaccines
Scientists at Emory Vaccine Center detail research in vaccines
May 27th, 2009
According to recent research published in the journal Nature Medicine, "Immune sensing of a microbe occurs via multiple receptors. How signals from different receptors are coordinated to yield a specific immune response is poorly understood." "We show that two pathogen recognition receptors, Toll-like receptor 2 (TLR2) and dectin-1, recognizing the same microbial stimulus, stimulate distinct innate and adaptive responses. TLR2 signaling induced splenic dendritic cells (DCs) to express the retinoic acid metabolizing enzyme retinaldehyde dehydrogenase type 2 and interleukin-10 (IL-10) and to metabolize vitamin A and stimulate Foxp(3+) T regulatory cells (T-reg...
Source: Vaccine Weekly (2009-05-27)
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