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Immunization
Research from University of Washington reveals new findings on immunization
May 27th, 2009
According to recent research from the United States, "We have previously demonstrated that transplanted cells from the SW I clone of the K1735 melanoma and the Ag104 sarcoma grow progressively in syngeneic C3H mice even after transfection to engage CD137, a procedure that increases the immunogenicity of many other tumors." "We now show that SW1 and Ag104 cells produce high levels of transforming growth factor (TGF) beta 1. and that they can induce an antitumor response if they Lire transfected with a nonreplicating lentivirus vector to ''silence'' the TGF beta 1 gene via short hairpin RNA. Importantly. vaccination with SW1 or Ag104 cells, which do not make TGF beta 1....
Source: Vaccine Weekly (2009-05-27)
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