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Vaccine Weekly

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Proteomics



Studies from University of Colorado, Colorado Health Sciences Center provide new data on proteomics



June 3rd, 2009

New investigation results, 'Modulation of muramyl dipeptide stimulation of cytokine production by blood components,' are detailed in a study published in Clinical & Experimental Immunology. "Muramyl dipeptide (MDP) is the minimal active fragment of peptidoglycan of the cell wall of Gram-positive bacteria, with potential beneficial effects as a vaccine adjuvant. Peptidoglycans and MDP are recognized by the intracellular receptor NOD2 (nucleotide-binding oligomerization domain 2), leading to production of proinflammatory cytokines," scientists in the United States report.

"In the present study, it is shown that, despite stimulatory effects on isolated human...


Source: Vaccine Weekly (2009-06-03)

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