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Vaccinia Virus
Study data from M. Moutaftsi and co-authors update knowledge of vaccinia virus
June 3rd, 2009
According to a study from the United States, "The recent identification of a large array of different vaccinia virus-derived CD8(+) T-cell epitopes offers a unique opportunity to systematically analyze the correlation between protective efficacy and variables such as kinetics of expression and function of viral proteins, binding affinity to MHC molecules, immunogenicity, and viral antigen processing/presentation. In the current study, 49 different H-2(b) restricted epitopes were tested for their ability to protect peptide-immunized C57Bl/6 mice from lethal i.n. challenge with vaccinia virus." "The epitopes varied greatly in their ability to confer protection, ranging...
Source: Vaccine Weekly (2009-06-03)
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