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Life Sciences



Researchers from Medical University of Vienna, Department of Pathophysiology discuss findings in life sciences



June 3rd, 2009

Investigators publish new data in the report 'Aluminium per se and in the anti-acid drug sucralfate promotes sensitization via the oral route.' "Aluminium (ALUM) is used as experimental and clinical adjuvant for parenteral vaccine formulation. It is also contained in anti-acid drugs like sucralfate (SUC)," researchers in Vienna, Austria report.

"These anti-acids have been shown to cause sensitization to food proteins via elevation of the gastric pH. The aim of this study was to assess the oral adjuvant properties of ALUM, alone or contained in SUC, in a BALB/c mouse model. Mice were fed SUC plus ovalbumin (OVA) and compared with groups where ALUM or proton pump...


Source: Vaccine Weekly (2009-06-03)

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