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Allergies
Study data from Seoul National University provide new insights into allergies
June 3rd, 2009
"Recent studies have shown that by acting as strong T(H)1 response-inducing adjuvants, DNA immunostimulatory sequence oligdeoxynucleotides (ISS-ODNs) can be used in the treatment of allergic diseases, and efforts are being made to enhance these T(H)1 adjuvant actions. To determine whether intranasally delivered ISS-ODN/cholera toxin B (CTB) conjugate has enhanced antiallergic effects in an allergic rhinitis mouse model," researchers in Seoul, South Korea report. "BALB-c mice were sensitized with ovalbumin. Chemical conjugation of ISS-ODN and CTB was performed. After a single local intranasal administration of 50 mu g of ISS-ODN or high- and low-dose (50- and 5-mu g)...
Source: Vaccine Weekly (2009-06-03)
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