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DNA Vaccines
Research from Wuhan University has provided new information about DNA vaccines
June 3rd, 2009
According to recent research published in the journal Immunological Investigations, "Fusing antigens to cytotoxic T-lymphocyte antigen 4 (CTLA-4) represents an effective approach to enhance DNA vaccine efficacy. It has been speculated that the direct targeting of CTLA-4 fusion antigens to antigen-presenting cells (APCs) causes antigens to be processed and presented to T cells more efficiently, leading to a stronger immune response." "In the present study, dendritic cells (DCs), the most potent APCs, were generated from human monocytes. The specific binding of CTLA-4 fusion protein to DCs was investigated by flow cytometry," wrote Q.A. Xu and colleagues, Wuhan...
Source: Vaccine Weekly (2009-06-03)
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