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Tetanus
Studies from J. Dekruif and co-researchers update current data on tetanus
June 10th, 2009
"To study the contribution of antibody light (L) chains to the diversity and binding properties of immune repertoires, a phage display repertoire was constructed from a single human antibody L chain and a large collection of antibody heavy (H) chains harvested from the blood of two human donors immunized with tetanus toxoid (TT) vaccine. After selection for binding to TT, 129 unique antibodies representing 53 variable immunoglobulin H chain (V-H) gene rearrangements were isolated," scientists in Netherlands report. "This panel of anti-TT antibodies restricted to a single variable immunoglobulin L chain (V-L) could be organized into 17 groups binding non-competing...
Source: Vaccine Weekly (2009-06-10)
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