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Allergies
Research from Medical University of Vienna broadens understanding of allergies
June 10th, 2009
"Recombinant allergen-S-layer fusion proteins display a strongly reduced IgE-binding activity and promote the induction of allergen-specific Th0/1 cells and regulatory T cells. Such fusion proteins show a natural capacity to self-assemble into mono- or double-layer sheets reaching particle-like dimensions of 0.5-2 mu m. We were interested in finding out whether self-assembly was crucial for the immunological characteristics of allergen-S-layer fusion proteins," researchers in Vienna, Austria report. "The IgE-binding and mediator-releasing capacities of nonassembled and self-assembled rSbpA-Bet v 1, consisting of the major birch pollen allergen Bet v 1 and the S-layer...
Source: Vaccine Weekly (2009-06-10)
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