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Vaccine Weekly

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HIV/AIDS



Research from S. Gaseitsiwe and co-researchers in the area of HIV/AIDS published



June 10th, 2009

"Identification of major histocompatibility complex (MHC) class II binding peptides is a crucial step in rational vaccine design and immune monitoring. We designed a novel MHC class II molecule-peptide microarray binding assay and evaluated 346 peptides from already identified human immunodeficiency virus (HIV) epitopes and an additional set (n = 206) of 20-mer peptides, overlapping by 15 amino acid residues, from HIV type 1B (HIV-1B) gp160 and Nef as a paradigm," scientists in Stockholm, Sweden report.

"Peptides were attached via the N-terminal part to a linker that covalently binds to the epoxy glass slide. The 552 peptides were printed in triplicate on a single...


Source: Vaccine Weekly (2009-06-10)

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