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Life Sciences
Research results from M.P. Dodding and colleagues update understanding of life sciences
June 10th, 2009
"The vaccinia virus protein, F12, has been suggested to play an important role in microtubule-based transport of intracellular enveloped virus (IEV). We found that GFP-F12 is recruited to IEV moving on microtubules but is released from virus particles when they switch to actin-based motility," investigators in London, the United Kingdom report. "In the absence of F12, although the majority of IEV remain close to their peri-nuclear site of assembly, a small number of IEV still move with linear trajectories at speeds of 0.85 mu m s(-1), consistent with microtubule transport. Using a recombinant virus expressing GST-F12, we found that the viral protein E2 interacts...
Source: Vaccine Weekly (2009-06-10)
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