Vaccine Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Vaccine Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Phosphatase
Scientists at State University of New York publish research in phosphatase
June 10th, 2009
"The Vaccinia virus H1 gene product, VH1, is a dual specificity phosphatase that down-regulates the cellular antiviral response by dephosphorylating STAT1. The crystal structure of VH1, determined at 1.32 angstrom resolution, reveals a novel dimeric quaternary structure, which exposes two active sites spaced similar to 39 angstrom away from each other," scientists in the United States report. "VH1forms a stable dimer via an extensive domain swap of the N-terminal helix ( residues 1-20). In vitro, VH1 can dephosphorylate activated STAT1, in a reaction that is competed by the nuclear transport adapter importin alpha 5. Interestingly, VH1 is inactive with respect to STAT1...
Source: Vaccine Weekly (2009-06-10)
|
