Cancer
Data on cancer described by F. Serana et al
Published in Vaccine Weekly, June 10th, 2009
"Assessment of T-cell diversity, besides giving insights about the molecular basis of tumor antigen recognition, has clinical implications since it provides criteria for evaluating antigen-specific T cells clinically relevant for spontaneous and vaccine-induced anti-tumor activity. Melan-A is one of the melanoma antigens most frequently recognized by peripheral and tumor-infiltrating lymphocytes in HLA-A2+ melanoma patients," scientists in Brescia, Italy report.
"Many clinical trials involving anti-tumor vaccination have been conducted using modified versions of this peptide. We conducted an in-depth characterization of 210 T-cell receptor beta chain (TRB) clonotypes...
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Source: Vaccine Weekly (2009-06-10)
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