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Vaccinia Virus
Study results from K. Zurkova et al provide new insights into vaccinia virus
June 10th, 2009
"Recombinant vaccinia viruses (rVACV) expressing various tumor-associated antigens have been shown to elicit anti-tumor effect in numerous experimental models and clinical trials. We tested the hypotheses that rVACV expressing biologically active fms-like tyrosine kinase 3 ligand (Flt3L) would show higher immunogenicity than control viruses expressing only model antigen and that coexpression of Flt3L would influence anti-tumor activity of rVACV in the preventive and therapeutic arrangements of the in vivo experiment," scientists writing in the journal Oncology Reports report. "To answer these questions, we took advantage of the well-described model of...
Source: Vaccine Weekly (2009-06-10)
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