DNA Vaccines

Research from University of California, Medical Department yields new findings on DNA vaccines

Published in Vaccine Weekly, June 10th, 2009

According to a study from the United States, "Simian immunodeficiency virus (SIV) infection of rhesus macaques is a valuable animal model for human immunodeficiency virus (HIV)-1 vaccine development. Our laboratory recently described the immunogenicity and limited efficacy of a vif-deleted SIVmac239 proviral DNA (SIV/CMV Delta vif) vaccine."

"The current report characterizes immunogenicity and efficacy for the SIV/CMV Delta vif proviral DNA vaccine when co-inoculated with an optimized rhesus interleukin (rIL)-15 expression plasmid. Macaques co-inoculated with rIL-15 and SIV/CMV Delta vif proviral plasmids showed significantly improved SIV-specific CD8 T cell immunity...

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Source: Vaccine Weekly (2009-06-10)

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