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DNA Vaccines
Study data from University of Florida provide new insights into angiogenesis
June 10th, 2009
"The efficacy of novel monoclonal antibodies that neutralize the pro-angiogenic mediator, sphingosine-1-phosphate (S1P), were tested using in vitro and in vivo angiogenesis models, including choroidal neovascularization (CNV) induced by laser disruption of Bruch's membrane. S1P receptor levels in human brain choroid plexus endothelial cells (CPEC), human lung microvascular endothelial cells, human retinal vascular endothelial cells, and circulating endothelial progenitor cells were examined by semi-quantitative PCR," scientists writing in the journal Experimental Eye Research report. "The ability of murine or humanized anti-SIP monoclonal antibodies (mAbs) to...
Source: Vaccine Weekly (2009-06-10)
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