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HIV/AIDS
Research from C.A. Semeniuk and co-authors yields new data on HIV/AIDS
June 17th, 2009
"The p1 region of HIV-1 gag contains the frameshift stem-loop, gag-pol transframe and a protease cleavage site that are crucial for viral assembly, replication and infectivity. Identifying and characterizing CD8(+) epitopes that are under host immune selection in this region will help in designing effective vaccines for HIV-1," scientists in Winnipeg, Canada report. "An approach combining bioinformatical analysis and interferon gamma enzyme-linked immunosorbent spot (ELISPOT) assays is used to identify and characterize the epitopes. Potential human leukocyte antigen (HLA)-restricted epitopes were identified by correlating the positively-selected mutations with host HLA...
Source: Vaccine Weekly (2009-06-17)
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