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Influenza
Data on influenza described by researchers at University of London, Imperial College
June 17th, 2009
"We have generated a construct encoding a single-chain H-2D(b) mouse MHC class I molecule in which an influenza virus nucleoprotein (NP) epitope, amino acid sequence ASNENMDAM, is fused to mouse beta(2)-microglobulin and the D-b H chain via flexible linker sequences. This single-chain trimer (SCT) was efficiently expressed at the cell surface independently of TAP and endogenous beta(2)-microglobulin, and it was recognized directly and efficiently by specific T cells in vitro," researchers in London, the United Kingdom report. "A recombinant vaccinia virus encoding the D-b NP SCT primed a CD8(+) T cell response in C57BL/6 mice 4-fold greater than an equivalent virus...
Source: Vaccine Weekly (2009-06-17)
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