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Lupus
Reports from D. Zagury et al highlight recent research in lupus
June 17th, 2009
According to recent research published in the journal Proceedings of the National Academy of Sciences of the United States of America, "A major involvement of IFN alpha in the etiopathogenesis of systemic lupus erythematosus has been suggested by clinical observations, including the increase of serum levels of this cytokine in patients with active disease." "Supporting this hypothesis, we have shown that expression of IFN alpha from a recombinant adenovirus (IFN alpha Adv) precipitates lupus manifestations in genetically susceptible New Zealand Black (NZB) x New Zealand White (NZW)F-1 mice (NZB/W) but not in BALB/c mice. In the present investigation, we have...
Source: Vaccine Weekly (2009-06-17)
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