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Monoclonal Antibodies
New monoclonal antibodies data have been reported by P.Y. Jia and co-authors
June 17th, 2009
According to a study from Beijing, People's Republic of China, "Soman is an organophosphorus neurotoxin which inhibits the activity of acetylcholinesterase (AChE). The goal of this work was to find out whether antibodies against an organophosphorus hapten could protect mice from soman toxicity." "An organophosphorus hapten P6 was synthesized. Its chemical conjugates with limulus polyphemus hemocyanin and bovine serum albumin were used as immune antigen (P6-LPH) and detection antigen (P6-BSA), respectively. Eight hybridoma cell lines secreting monoclonal antibodies (Mabs) were established. The binding reactivities of Mabs with P6 and soman were determined by competitive...
Source: Vaccine Weekly (2009-06-17)
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