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Bacillus Calmette-Guerin Vaccines
Recent studies from University College add new data to Bacillus calmette-guerin vaccines
June 24th, 2009
"To further unravel the mechanisms responsible for attenuation of the tuberculosis vaccine Mycobacterium bovis BCG, comparative genomics was used to identify single nucleotide polymorphisms ( SNPs) that differed between sequenced strains of Mycobacterium bovis and M. bovis BCG. SNPs were assayed in M. bovis isolates from France and the United Kingdom and from different BCG vaccines in order to identify those that arose during the attenuation process which gave rise to BCG," investigators in Dublin, Ireland report. "Informative data sets were obtained for 658 SNPs from 21 virulent M. bovis strains and 13 BCG strains; these SNPs showed phylogenetic clustering that was...
Source: Vaccine Weekly (2009-06-24)
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