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Vaccine Weekly

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Encephalitis



Reports summarize encephalitis study results from V.D. Krishna and co-researchers



June 24th, 2009

According to recent research from Bangalore, India, "We demonstrate the presence of nonstructural protein 1 (NS1)-specific antibodies in a significant proportion of convalescent-phase human serum samples obtained from a cohort in an area where Japanese encephalitis virus (JEV) is endemic. Sera containing antibodies to NS1 but not those with antibodies to other JEV proteins, such as envelope, brought about complement-mediated lysis of JEV-infected BHK-21 cells."

"Target cells infected with a recombinant poxvirus expressing JEV NS1 on the cell surface confirmed the NS1 specificity of cytolytic antibodies. Mouse anti-NS1 cytolytic sera caused a complement-dependent...


Source: Vaccine Weekly (2009-06-24)

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