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Pneumococcal Disease
Studies from University of Adelaide reveal new findings on pneumococcal disease
July 1st, 2009
"The pneumococcal histidine triad (Pht) proteins are a recently recognized family of surface proteins, comprising 4 members: PhtA, PhtB, PhtD, and PhtE. They are being promoted for inclusion in a multicomponent pneumococcal protein vaccine currently under development, but to date, their biological functions and their relative contributions to pathogenesis have not been clarified," scientists writing in the Faseb Journal report. "In this study, the involvement of these proteins in pneumococcal virulence was investigated in murine models of sepsis and pneumonia by using defined, nonpolar mutants of the respective genes in Streptococcus pneumoniae D39. In either...
Source: Vaccine Weekly (2009-07-01)
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