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Immunization
Research on immunization discussed by A.V. Misharin and co-researchers
July 8th, 2009
According to recent research from the United States, "Vaccination with cDNA for the human thyrotropin receptor (TSHR) in a plasmid, without adjuvant, induces TSHR antibodies in C57BL/6 but rarely in BALB/c mice. This outcome could be due to a difference between ''high'' versus ''low'' antibody responder mouse strains." "However, unlike their poor response to TSHR-DNA vaccination, BALB/c mice vaccinated with thyroid peroxidase (TPO)-cDNA readily develop antibodies to TPO. We hypothesized that insight into these conundrums would be provided by the following differences in central tolerance: (i) between two mouse strains (C57BL/6 versus BALB/c) for the TSHR; and (ii)...
Source: Vaccine Weekly (2009-07-08)
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