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Meningococcal Disease
Study data from University of Sheffield update understanding of meningococcal disease
July 8th, 2009
According to recent research from Sheffield, the United Kingdom, "After adolescence, the incidence of meningococcal disease decreases with age as a result of the cumulative immunizing effect of repeated nasopharyngeal colonization. Nevertheless, some adults succumb to meningococcal disease, so we hypothesized that this is due to a subtle functional immunological defect." "Peripheral blood lymphocytes derived from survivors of serogroup C meningococcal disease and from age- and sex-matched controls were incubated with a polyclonal B-cell activator containing anti-immunoglobulin D (alpha-delta-dex) employed to mimic antigen-specific stimuli encountered during immune...
Source: Vaccine Weekly (2009-07-08)
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